This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful. More information in our Privacy Policy
FINE
Fluorinated PLGA-PEO dendrImers as 19F MRI Nanotheranostics for ostEosarcoma management
Principal investigator: Monica Montesi
Personnel involved: Silvia Panseri, Lorenzo Apolloni
Starting date: 16/10/2023
Duration: 24 months
Total funding: 225.680,00 €
Action: PRIN: PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE – Bando 2022
CNR-ISSMC role: Partner
Coordinator: Prof. Angela Scala (Università di Messina)
Consortium: 2 partners
FINE project aims to synthesize new fluorinated dendrimers based on poly(lactide-co-glycolic acid) (PLGA) and poly(ethylene oxide) (PEO) combining amphiphilic properties, controllable functionalities, pH-sensitive hydrazone units and high content of chemically equivalent fluorine atoms, with the aim to develop novel pH-responsive drug nanocarriers and 19F-MRI nanoprobes (NanoDenFluo) for osteosarcoma management. The activity of ISSMC is related to evaluating the NanoDenFluo biological performances in a more predictive 3D scaffold-based cancer model, recapitulating more in detail the complexity of the cancer tissue in vivo and reducing the limitation of the standard in vitro
2D culture systems.