Fluorinated PLGA-PEO dendrImers as 19F MRI Nanotheranostics for ostEosarcoma management

Principal investigator: Monica Montesi

Personnel involved: Silvia Panseri, Lorenzo Apolloni

Starting date: 16/10/2023
Duration: 24 months
Total funding: 225.680,00 €
Action: PRIN: PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE – Bando 2022
CNR-ISSMC role: Partner
Coordinator: Prof. Angela Scala (Università di Messina)
Consortium: 2 partners

FINE project aims to synthesize new fluorinated dendrimers based on poly(lactide-co-glycolic acid) (PLGA) and poly(ethylene oxide) (PEO) combining amphiphilic properties, controllable functionalities, pH-sensitive hydrazone units and high content of chemically equivalent fluorine atoms, with the aim to develop novel pH-responsive drug nanocarriers and 19F-MRI nanoprobes (NanoDenFluo) for osteosarcoma management. The activity of ISSMC is related to evaluating the NanoDenFluo biological performances in a more predictive 3D scaffold-based cancer model, recapitulating more in detail the complexity of the cancer tissue in vivo and reducing the limitation of the standard in vitro
2D culture systems.